Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.

ABSTRACT:

Importance

Sex differences are established in associations between apolipoprotein E (APOE) ε4 and cognitive impairment in Alzheimer disease (AD). However, it is unclear whether sex-specific cognitive consequences of APOE are consistent across races and extend to the APOE ε2 allele.

Objective

To investigate whether sex and race modify APOE ε4 and ε2 associations with cognition.

Design, setting, and participants

This genetic association study included longitudinal cognitive data from 4 AD and cognitive aging cohorts. Participants were older than 60 years and self-identified as non-Hispanic White or non-Hispanic Black (hereafter, White and Black). Data were previously collected across multiple US locations from 1994 to 2018. Secondary analyses began December 2021 and end

SUBMITTER: Walters S 

PROVIDER: S-EPMC10352930 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature