Ontology highlight
ABSTRACT:
SUBMITTER: Xiong R
PROVIDER: S-EPMC10353054 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Xiong Ruoyun R Gunter Courtney C Fleming Elizabeth E Vernon Suzanne D SD Bateman Lucinda L Unutmaz Derya D Oh Julia J
Cell host & microbe 20230201 2
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, debilitating disorder manifesting as severe fatigue and post-exertional malaise. The etiology of ME/CFS remains elusive. Here, we present a deep metagenomic analysis of stool combined with plasma metabolomics and clinical phenotyping of two ME/CFS cohorts with short-term (<4 years, n = 75) or long-term disease (>10 years, n = 79) compared with healthy controls (n = 79). First, we describe microbial and metabolomic dysbiosi ...[more]