Transcriptional activity of the long control region in human papillomavirus type 33 intratype variants.

ABSTRACT:

Background

High-risk human papillomaviruses (HPVs) are responsible for the development of cervical and other anogenital cancers. Intratype sequence variants of certain high-risk HPV types (e.g. 16, 18 and 31) are thought to have different oncogenic potential, partly due to nucleotide sequence variation in the viral long control region (LCR). The LCR has an important role in the regulation of viral replication and transcription. The purpose of this study was to explore sequence variation in the LCR of HPV 33 intratype variants in Hungary and to see whether there are differences in the transcriptional activities of the variants.

Methods

The complete HPV 33 LCR was amplified from HPV 33 positive cervical samples. After sequencing the LCR variants, multiple sequence alignment an

SUBMITTER: Gyongyosi E 

PROVIDER: S-EPMC10353102 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature