Reduced polymorphism of Plasmodium vivax early transcribed membrane protein (PvETRAMP) 11.2.

ABSTRACT:

Background

ETRAMP11.2 (PVX_003565) is a well-characterized protein with antigenic potential. It is considered to be a serological marker for diagnostic tools, and it has been suggested as a potential vaccine candidate. Despite its immunological relevance, the polymorphism of the P. vivax ETRAMP11.2 gene (pvetramp11.2) remains undefined. The genetic variability of an antigen may limit the effectiveness of its application as a serological surveillance tool and in vaccine development and, therefore, the aim of this study was to investigate the genetic diversity of pvetramp11.2 in parasite populations from Amazonian regions and worldwide. We also evaluated amino acid polymorphism on predicted B-cell epitopes. The low variability of the sequence encoding PvETRAMP11.2 protein suggests th

SUBMITTER: Perrotti E 

PROVIDER: S-EPMC10353105 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature