Novel complete methanogenic pathways in longitudinal genomic study of monogastric age-associated archaea.

ABSTRACT:

Background

Archaea perform critical roles in the microbiome system, including utilizing hydrogen to allow for enhanced microbiome member growth and influencing overall host health. With the majority of microbiome research focusing on bacteria, the functions of archaea are largely still under investigation. Understanding methanogenic functions during the host lifetime will add to the limited knowledge on archaeal influence on gut and host health. In our study, we determined lifelong archaea dynamics, including detection and methanogenic functions, while assessing global, temporal and host distribution of our novel archaeal metagenome-assembled genomes (MAGs). We followed 7 monogastric swine throughout their life, from birth to adult (1-156 days of age), and collected feces at 22 tim

SUBMITTER: Feehan B 

PROVIDER: S-EPMC10353118 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature