Association of immune cell composition with the risk factors and incidence of acute coronary syndrome.

ABSTRACT:

Background

Although immune cells are involved in acute coronary syndrome (ACS), few studies have explored the association of incident ACS with the relative immune cell proportions. We aimed to investigate the association of immune cell proportions with the incidence and risk factors of ACS in the Dongfeng-Tongji cohort.

Methods

We conducted the analyses with 38,295 subjects from the first follow-up of the Dongfeng-Tongji cohort, including DNA methylation profiles for 1570 individuals. The proportions of immune cell types were observed from routine blood tests or estimated from DNA methylation profiles. For both observed and estimated immune cell proportions, we tested their associations with risk factors of ACS by multivariable linear regression models. In addition, the asso

SUBMITTER: Shi X 

PROVIDER: S-EPMC10353119 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature