Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development.

ABSTRACT: Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart failure and even death. Multiple biological processes, such as smooth muscle proliferation, endothelial dysfunction, inflammation, and resistance to apoptosis, are associated with PAH. Increasing evidence suggests that epigenetic factors play an important role in PAH by regulating the chromatin structure and altering the expression of critical genes. For example, aberrant DNA methylation and histone modifications such as histone acetylation and methylation have been observed in patients with PAH and are linked to vascular remodeling and pulmonary vascular dysfunction. In this review article, we provide a comprehensive

SUBMITTER: Dave J 

PROVIDER: S-EPMC10353122 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature