Elevated plasma factor XI predicts cardiovascular events in patients with type 2 diabetes: a long-term observational study.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) patients are at high risk of cardiovascular (CV) events. Factor XI (FXI) is associated with arterial thromboembolism, including myocardial infarction (MI), stroke, and CV mortality. The role of FXI in T2DM is unknown. We investigated whether plasma FXI is associated with CV events in T2DM patients in long-term observation.

Methods

In 133 T2DM patients (aged 66 ± 8 years, 40.6% women, median T2DM duration 5 [2-10] years) we assessed plasma FXI levels, along with fibrin clot properties, thrombin generation, and fibrinolysis proteins. A composite endpoint of MI, stroke, or CV death, as well as CV mortality alone were assessed during a median follow-up of 72 months.

Results

Plasma FXI above the 120% upper normal limit was detecte

SUBMITTER: Paszek E 

PROVIDER: S-EPMC10353137 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature