SNHG1 opposes quiescence and promotes docetaxel sensitivity in prostate cancer.

ABSTRACT:

Background

A majority of prostate cancer cells are in a non-proliferating, G₀ (quiescent) phase of the cell cycle and may lie dormant for years before activation into a proliferative, rapidly progressing, disease phase. Many mechanisms which influence proliferation and quiescence choices remain to be elucidated, including the role of non-coding RNAs. In this study, we investigated the role of a long non-coding RNA (lncRNA), SNHG1, on cell proliferation, quiescence, and sensitivity to docetaxel as a potential factor important in prostate cancer biology.

Methods

Publically available, anonymous, clinical data was obtained from cBioPortal for analysis. RNAi and prostate cancer cell lines were utilized to investigate SNHG1 in vitro. We measured G₀ cells, DNA

SUBMITTER: Zielske SP 

PROVIDER: S-EPMC10353248 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature