Network pharmacology and molecular docking to explore Polygoni Cuspidati Rhizoma et Radix treatment for acute lung injury.

ABSTRACT:

Background

Polygoni Cuspidati Rhizoma et Radix (PCRR), a well-known traditional Chinese medicine (TCM), inhibits inflammation associated with various human diseases. However, the anti-inflammatory effects of PCRR in acute lung injury (ALI) and the underlying mechanisms of action remain unclear.

Aim

To determine the ingredients related to PCRR for treatment of ALI using multiple databases to obtain potential targets for fishing.

Methods

Recognized and candidate active compounds for PCRR were obtained from Traditional Chinese Medicine Systems Pharmacology, STITCH, and PubMed databases. Target ALI databases were built using the Therapeutic Target, DrugBank, DisGeNET, Online Mendelian Inheritance in Man, and Genetic Association databases. Network pharmacology includes net

SUBMITTER: Zheng JL 

PROVIDER: S-EPMC10353494 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature