Intratumoural microbiome can predict the prognosis of hepatocellular carcinoma after surgery.

ABSTRACT:

Background

The dismal prognosis of hepatocellular carcinoma (HCC) is closely associated with characteristics of the tumour microenvironment (TME). Recent studies have confirmed the presence and potential influence of the microbiome in TME on cancer progression. Elucidating the relationship between microbes in the TME and cancer could provide valuable insights into novel diagnostic markers and therapeutic strategies for HCC and thus warrants a closer investigation of the role of intratumoural microbiome in the HCC TME.

Methods

We determined the presence of intratumoural microbiome using fluorescence in situ hybridisation, and explored the microbial community profiles in the HCC TME in paired tumour and adjacent normal tissues using 16S rDNA sequencing. Microbial signatures we

SUBMITTER: Sun L 

PROVIDER: S-EPMC10353526 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature