Ontology highlight
ABSTRACT:
SUBMITTER: Akter M
PROVIDER: S-EPMC10353567 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Akter Masuma M Cui Haochen H Abir Hosain Md M Ding Baojin B
Stem cell research 20230321
Mutations in the RNA-binding protein FUS (fused in sarcoma) are linked to amyotrophic lateral sclerosis (ALS), but the pathogenesis is not fully understood. For modeling ALS, here we generated two induced pluripotent stem cell (iPSC) lines carrying the heterozygous and homozygous R521G (c.1561C > G) mutation in the FUS gene via genetic modification of a healthy hiPSC line (WTC11, UCSFi001-A). Both lines show normal stem cell morphology and karyotype, express pluripotent markers, and can differen ...[more]