Altered resting-state functional connectivity patterns in late middle-aged and older adults with obstructive sleep apnea.

ABSTRACT:

Introduction

Obstructive sleep apnea (OSA) is increasingly recognized as a risk factor for cognitive decline, and has been associated with structural brain alterations in regions relevant to memory processes and Alzheimer's disease. However, it is unclear whether OSA is associated with disrupted functional connectivity (FC) patterns between these regions in late middle-aged and older populations. Thus, we characterized the associations between OSA severity and resting-state FC between the default mode network (DMN) and medial temporal lobe (MTL) regions. Second, we explored whether significant FC changes differed depending on cognitive status and were associated with cognitive performance.

Methods

Ninety-four participants [24 women, 65.7 ± 6.9 years old, 41% with Mild Cognit

SUBMITTER: Martinez Villar G 

PROVIDER: S-EPMC10353887 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature