Gene expression analysis during progression of malignant meningioma compared to benign meningioma.

ABSTRACT:

Objective

Meningioma is the most common primary intracranial neoplasm. Only 1%-3% of meningiomas are malignant according to the 2016 WHO criteria (WHO grade III). High-grade meningiomas present specific gene expression signatures indicating aggressive growth or recurrence. However, changes in gene expression and in neuroinflammatory gene expression signatures in WHO grade III meningiomas and during progression from WHO grade I or II to grade III are unknown.

Methods

The authors used a NanoString targeted gene expression panel with focus on 787 genes relevant in meningioma pathology and neuroinflammatory pathways to investigate patients with grade III meningiomas treated at Rigshospitalet from 2000 to 2020 (n = 51). A temporal dimension was added to the investigation by inclu

SUBMITTER: Maier AD 

PROVIDER: S-EPMC10353908 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature