The effect of recombinant erythropoietin on long-term outcome after moderate-to-severe traumatic brain injury.

ABSTRACT:

Purpose

Recombinant erythropoietin (EPO) administered for traumatic brain injury (TBI) may increase short-term survival, but the long-term effect is unknown.

Methods

We conducted a pre-planned long-term follow-up of patients in the multicentre erythropoietin in TBI trial (2010-2015). We invited survivors to follow-up and evaluated survival and functional outcome with the Glasgow Outcome Scale-Extended (GOSE) (categories 5-8 = good outcome), and secondly, with good outcome determined relative to baseline function (sliding scale). We used survival analysis to assess time to death and absolute risk differences (ARD) to assess favorable outcomes. We categorized TBI severity with the International Mission for Prognosis and Analysis of Clinical Trials in TBI model. Heterogeneity o

SUBMITTER: Skrifvars MB 

PROVIDER: S-EPMC10353955 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature