Dataset Information

LPF: a framework for exploring the wing color pattern formation of ladybird beetles in Python.

ABSTRACT:

Summary

Biological pattern formation is one of the complex system phenomena in nature, requiring theoretical analysis based on mathematical modeling and computer simulations for in-depth understanding. We propose a Python framework named LPF to systematically explore the highly diverse wing color patterns of ladybirds using reaction-diffusion models. LPF supports GPU-accelerated array computing for numerical analysis of partial differential equation models, concise visualization of ladybird morphs, and evolutionary algorithms for searching mathematical models with deep learning models for computer vision.

Availability and implementation

LPF is available on GitHub at https://github.com/cxinsys/lpf.

SUBMITTER: Lee D

PROVIDER: S-EPMC10354001 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

LPF: a framework for exploring the wing color pattern formation of ladybird beetles in Python.

Lee Daewon D

Bioinformatics (Oxford, England) 20230701 7

<h4>Summary</h4>Biological pattern formation is one of the complex system phenomena in nature, requiring theoretical analysis based on mathematical modeling and computer simulations for in-depth understanding. We propose a Python framework named LPF to systematically explore the highly diverse wing color patterns of ladybirds using reaction-diffusion models. LPF supports GPU-accelerated array computing for numerical analysis of partial differential equation models, concise visualization of ladyb ...[more]

PMID: 37421407

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Project description:BackgroundButterfly wing color patterns are an important model system for understanding the evolution and development of morphological diversity and animal pigmentation. Wing color patterns develop from a complex network composed of highly conserved patterning genes and pigmentation pathways. Patterning genes are involved in regulating pigment synthesis however the temporal expression dynamics of these interacting networks is poorly understood. Here, we employ next generation sequencing to examine expression patterns of the gene network underlying wing development in the nymphalid butterfly, Vanessa cardui.ResultsWe identified 9, 376 differentially expressed transcripts during wing color pattern development, including genes involved in patterning, pigmentation and gene regulation. Differential expression of these genes was highest at the pre-ommochrome stage compared to early pupal and late melanin stages. Overall, an increasing number of genes were down-regulated during the progression of wing development. We observed dynamic expression patterns of a large number of pigment genes from the ommochrome, melanin and also pteridine pathways, including contrasting patterns of expression for paralogs of the yellow gene family. Surprisingly, many patterning genes previously associated with butterfly pattern elements were not significantly up-regulated at any time during pupation, although many other transcription factors were differentially expressed. Several genes involved in Notch signaling were significantly up-regulated during the pre-ommochrome stage including slow border cells, bunched and pebbles; the function of these genes in the development of butterfly wings is currently unknown. Many genes involved in ecdysone signaling were also significantly up-regulated during early pupal and late melanin stages and exhibited opposing patterns of expression relative to the ecdysone receptor. Finally, a comparison across four butterfly transcriptomes revealed 28 transcripts common to all four species that have no known homologs in other metazoans.ConclusionsThis study provides a comprehensive list of differentially expressed transcripts during wing development, revealing potential candidate genes that may be involved in regulating butterfly wing patterns. Some differentially expressed genes have no known homologs possibly representing genes unique to butterflies. Results from this study also indicate that development of nymphalid wing patterns may arise not only from melanin and ommochrome pigments but also the pteridine pigment pathway.

Dataset Information

LPF: a framework for exploring the wing color pattern formation of ladybird beetles in Python.

Summary

Availability and implementation

Publications

LPF: a framework for exploring the wing color pattern formation of ladybird beetles in Python.

Similar Datasets

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