Ontology highlight
ABSTRACT:
SUBMITTER: Russell Lewis B
PROVIDER: S-EPMC10354078 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Russell Lewis Benjamin B Uddin Muhammad R MR Moniruzzaman Mohammad M Kuo Katie M KM Higgins Anna J AJ Shah Laila M N LMN Sobott Frank F Parks Jerry M JM Hammerschmid Dietmar D Gumbart James C JC Zgurskaya Helen I HI Reading Eamonn E
Nature communications 20230718 1
Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite multidrug efflux pump system from Escherichia coli, AcrAB-TolC, is a target for inhibition to lessen resistance development and restore antibiotic efficacy, with homologs in other ESKAPE pathogens. Here, we rationalize a mechanism of inhibition against the periplasmic adaptor protein, AcrA, using a combination of hydrogen/deuterium exchange mass spectrometry, cellular efflux assays, and molecular dynamics s ...[more]