Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology.

ABSTRACT: Ample evidence suggests that acute stress can worsen symptom severity in Tourette syndrome (TS); however, the neurobiological underpinnings of this phenomenon remain poorly understood. We previously showed that acute stress exacerbates tic-like and other TS-associated responses via the neurosteroid allopregnanolone (AP) in an animal model of repetitive behavioral pathology. To verify the relevance of this mechanism to tic pathophysiology, here we tested the effects of AP in a mouse model recapitulating the partial depletion of dorsolateral cholinergic interneurons (CINs) seen in post-mortem studies of TS. Mice underwent targeted depletion of striatal CINs during adolescence and were tested in young adulthood. Compared with controls, partially CIN-depleted male mice exhibited several TS-rel

SUBMITTER: Cadeddu R 

PROVIDER: S-EPMC10354086 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature