Examination of potentially modifiable dementia risk factors across the adult life course: The Framingham Heart Study.

ABSTRACT:

Introduction

We examined for associations between potentially modifiable risk factors across the adult life course and incident dementia.

Methods

Participants from the Framingham Heart Study were included (n = 4015). Potential modifiable risk factors included education, alcohol intake, smoking, body mass index (BMI), physical activity, social network, diabetes, and hypertension. Cox models were used to examine associations between each factor and incident dementia, stratified by early adult life (33-44 years), midlife (45-65 years), and late life (66-80 years).

Results

Increased dementia risk was associated with diabetes (hazard ratio [HR] = 1.62; 95% confidence interval [CI] = 1.07-2.46) and physical inactivity (HR = 1.57; 95% CI = 1.12-2.20) in midlife, and with obe

SUBMITTER: Hwang PH 

PROVIDER: S-EPMC10354206 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature