Gene expression analysis in recurrent benign paroxysmal positional vertigo: a preliminary study.

ABSTRACT:

Objectives

This study aimed to determine the pathophysiology of recurrent benign paroxysmal positional vertigo (BPPV) in young patients using gene expression profiling combined with bioinformatics analysis.

Methods

Total RNA was extracted from the whole blood of four young patients with recurrent BPPV and four controls. The differentially expressed genes (DEGs) between the groups were screened using a microarray analysis based on the cutoff criteria of |log₂ fold change| > 1 and an adjusted p-value of < 0.05. Functional enrichment analysis of DEGs was performed using Gene Ontology analysis, and the protein-protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of the Interacting Genes database.

Results

A total of 39

SUBMITTER: Oh EH 

PROVIDER: S-EPMC10354243 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature