Salmonella gallinarum strains from outbreaks of fowl typhoid fever in Southern Africa closely related to SG9R vaccines.

ABSTRACT:

Introduction

Salmonella enterica subspecies enterica serovar Gallinarum biovar Gallinarum (SG) is associated with fowl typhoid fever, and the attenuated rough strain SG9R is widely used as a vaccine in many regions. Reversion to virulence of vaccine strains was suspected as the cause during recent fowl typhoid fever outbreaks in poultry in South Africa and Eswatini.

Methods

To compare nine field isolates with global wild-type SG9 strains and the two commercial SG9R vaccines in use, Nobilis^® SG9R and Cevac^®-SG, we used whole-genome comparison with single-nucleotide polymorphism (SNP) detection.

Results

SNP phylogenic analysis showed that all the southern African field isolates were more closely related to the vaccine strains than wil

SUBMITTER: Beylefeld A 

PROVIDER: S-EPMC10354334 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature