Delayed closed-loop neurostimulation for the treatment of pathological brain rhythms in mental disorders: a computational study.

ABSTRACT: Mental disorders are among the top most demanding challenges in world-wide health. A large number of mental disorders exhibit pathological rhythms, which serve as the disorders characteristic biomarkers. These rhythms are the targets for neurostimulation techniques. Open-loop neurostimulation employs stimulation protocols, which are rather independent of the patients health and brain state in the moment of treatment. Most alternative closed-loop stimulation protocols consider real-time brain activity observations but appear as adaptive open-loop protocols, where e.g., pre-defined stimulation sets in if observations fulfil pre-defined criteria. The present theoretical work proposes a fully-adaptive closed-loop neurostimulation setup, that tunes the brain activities power spectral density (P

SUBMITTER: Wahl T 

PROVIDER: S-EPMC10354341 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature