Glucose metabolism and its role in the maturation and migration of human CD1c⁺ dendritic cells following exposure to BCG.

ABSTRACT:

Introduction

Tuberculosis (TB) still kills over 1 million people annually. The only approved vaccine, BCG, prevents disseminated disease in children but shows low efficacy at preventing pulmonary TB. Myeloid dendritic cells (mDCs) are promising targets for vaccines and immunotherapies to combat infectious diseases due to their essential role in linking innate and adaptive immune responses. DCs undergo metabolic reprogramming following exposure to TLR agonists, which is thought to be a prerequisite for a successful host response to infection. We hypothesized that metabolic rewiring also plays a vital role in the maturation and migration of DCs stimulated with BCG. Consequently, we investigated the role of glycolysis in the activation of primary human myeloid CD1c⁺ DCs in

SUBMITTER: Triglia D 

PROVIDER: S-EPMC10354370 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature