A numerical study of a left ventricular expander for heart failure with preserved ejection fraction.

ABSTRACT: Increased cardiac stiffness hinders proper left ventricular (LV) expansion, resulting in decreased volume and diastolic dysfunction. LV expanders are spring-like devices designed to improve diastolic function by facilitating mechanical outward expansion. Implantations in animals and humans have shown promising results, yet further evaluation is needed to assess a range of functions and the risk of use. In this computational study, the effectiveness and potential use of a generic LV expander were assessed by using previously generated finite-element models of induced heart failure with preserved ejection fraction (HFpEF). Following implantation, the treated models were compared to the corresponding untreated and healthy pre-induction models. The influence of device orientation and its mater

SUBMITTER: Weissmann J 

PROVIDER: S-EPMC10354470 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature