Anti-osteoporotic drugs affect the pathogenesis of gut microbiota and its metabolites: a clinical study.

ABSTRACT:

Background

Disordered gut microbiota (GM) structure and function may contribute to osteoporosis (OP). This study explores how traditional Chinese medicine (TCM) intervention affects the structure and function of the GM in patients with OP.

Method

In a 3-month clinical study, 43 patients were randomly divided into two groups receiving conventional treatment and combined TCM (Yigu decoction, YGD) treatment. The correlation between the intestinal flora and its metabolites was analyzed using 16S rDNA and untargeted metabolomics and the combination of the two.

Results

After three months of treatment, patients in the treatment group had better bone mineral density (BMD) than those in the control group (P < 0.05). Patients in the treatment group had obvious abundance

SUBMITTER: Zhang RK 

PROVIDER: S-EPMC10354646 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature