Extracorporeal Membrane Oxygenation for Refractory Asthma Exacerbations With Respiratory Failure.

ABSTRACT:

Background

Asthma exacerbations with respiratory failure (AERF) are associated with hospital mortality of 7% to 15%. Extracorporeal membrane oxygenation (ECMO) has been used as a salvage therapy for refractory AERF, but controlled studies showing its association with mortality have not been performed.

Research question

Is treatment with ECMO associated with lower mortality in refractory AERF compared with standard care?

Study design and methods

This is a retrospective, epidemiologic, observational cohort study using a national, administrative data set from 2010 to 2020 that includes 25% of US hospitalizations. People were included if they were admitted to an ECMO-capable hospital with an asthma exacerbation, and were treated with short-acting bronchodilators, systemic

SUBMITTER: Zakrajsek JK 

PROVIDER: S-EPMC10354700 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature