Reverse remodelling and recovery from heart failure are associated with complex patterns of gene expression.

ABSTRACT: Combined left ventricular assist device (LVAD) support and pharmacological management of the failing heart can induce reversal of maladaptive cardiac remodelling leading to normalisation of cardiac structure and recovery of cardiac function. The purpose of this study was to compare the gene expression profiles of recovered and non-recovered LVAD patients in order to identify mechanisms underlying the recovery process and differences which may determine outcome. Myocardial expression of 54 genes chosen for their potential role in heart failure and tissue repair was measured using quantitative PCR at the time of LVAD implantation and again at explantation (recovery, n = 13) or transplantation (non-recovery, n = 5). Patients who went on to recover had higher levels of Giα2, EPAC2 and lower le

SUBMITTER: Felkin LE 

PROVIDER: S-EPMC10354734 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature