Biomimetic in situ tracheal microvascularization for segmental tracheal reconstruction in one-step.

ABSTRACT: Formation of functional and perfusable vascular network is critical to ensure the long-term survival and functionality of the engineered tissue tracheae after transplantation. However, the greatest challenge in tracheal-replacement therapy is the promotion of tissue regeneration by rapid graft vascularization. Traditional prevascularization methods for tracheal grafts typically utilize omentum or muscle flap wrapping, which requires a second operation; vascularized segment tracheal orthotopic transplantation in one step remains difficult. This study proposes a method to construct a tissue-engineered tracheal graft, which directly forms the microvascular network after orthotopic transplantation in vivo. The focus of this study was the preparation of a hybrid tracheal graft that is non-immun

SUBMITTER: Sun F 

PROVIDER: S-EPMC10354772 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature