Tolerance limit of external beam radiotherapy combined with low-dose rate brachytherapy in normal rabbit tissue.

ABSTRACT:

Background

Dosage-optimized multimodal radiotherapies that are safe for head and neck cancer patients are desirable. In this study, we investigated tissue tolerance to varying doses of external beam radiotherapy (EBRT) combined with low-dose rate brachytherapy in the neck of a rabbit model.

Methods

Twenty rabbits were used in the four test groups (five each) with iodine-125 seeds implanted in the neck treated with EBRT in four doses at 50, 40, 30 and 20 Gy each. Twelve rabbits for three control groups (four each). Three months after implantation, all rabbits were euthanized, and target tissues were collected. Analyses included seed implantation assessment, histopathological evaluation, immunohistochemistry staining, terminal deoxynucleotidyl transferase dUTP nick end labelin

SUBMITTER: Ling H 

PROVIDER: S-EPMC10354847 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature