Long-term Safety and Tolerability of Omadacycline for the Treatment of Mycobacterium abscessus Infections.

ABSTRACT:

Background

Mycobacterium abscessus is a virulent human pathogen. Treatment is complex and often poorly tolerated with suboptimal rates of eradication, highlighting the need for improved therapeutics. This study reports clinical experience with omadacycline for treatment of M abscessus infections at five large nontuberculous mycobacterial (NTM) disease clinics across the United States to better understand long-term safety and tolerability.

Methods

We conducted a multicenter retrospective chart review of adults with M abscessus infections. All patients treated with omadacycline as part of a multidrug therapeutic regimen through December 2021 were included. Clinical data from time of omadacycline initiation and up to 12 months of follow-up were collected. D

SUBMITTER: Mingora CM 

PROVIDER: S-EPMC10354853 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature