Causal effects of COVID-19 on structural changes in specific brain regions: a Mendelian randomization study.

ABSTRACT:

Background

Previous studies have found a correlation between coronavirus disease 2019 (COVID-19) and changes in brain structure and cognitive function, but it remains unclear whether COVID-19 causes brain structural changes and which specific brain regions are affected. Herein, we conducted a Mendelian randomization (MR) study to investigate this causal relationship and to identify specific brain regions vulnerable to COVID-19.

Methods

Genome-wide association study (GWAS) data for COVID-19 phenotypes (28,900 COVID-19 cases and 3,251,161 controls) were selected as exposures, and GWAS data for brain structural traits (cortical thickness and surface area from 51,665 participants and volume of subcortical structures from 30,717 participants) were selected as outcomes. Inverse-va

SUBMITTER: Zhou S 

PROVIDER: S-EPMC10354891 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature