Early non-response as a predictor of later non-response to antipsychotics in schizophrenia: a randomized trial.

ABSTRACT:

Background

It remains a challenge to predict the long-term response to antipsychotics in patients with schizophrenia who do not respond at an early stage. This study aimed to investigate the optimal predictive cut-off value for early non-response that would better predict later non-response to antipsychotics in patients with schizophrenia.

Methods

This multicenter, 8-week, open-label, randomized trial was conducted at 19 psychiatric centers throughout China. All enrolled participants were assigned to olanzapine, risperidone, amisulpride, or aripiprazole monotherapy for 8 weeks. The positive and negative syndrome scale (PANSS) was evaluated at baseline, week 2, week 4, and week 8. The main outcome was the prediction of nonresponse. Nonresponse is defined as a < 20% reduction

SUBMITTER: Long Y 

PROVIDER: S-EPMC10354903 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature