Combining perineural invasion with staging improve the prognostic accuracy in colorectal cancer: a retrospective cohort study.

ABSTRACT:

Background

Current guidelines only propose the importance of perineural invasion(PNI) on prognosis in stage II colon cancer. However, the prognostic value of PNI in other stages of colorectal cancer (CRC) is ambiguous.

Methods

This single-center retrospective cohort study included 3485 CRC patients who underwent primary colorectal resection between January 2013 and December 2016 at the Sixth Affiliated Hospital of Sun Yat-sen University. Associations of PNI with overall survival (OS) and disease-free survival (DFS) were evaluated using multivariable Cox proportional hazards regression models. In addition, interaction analyses were performed to explore the prognostic effects of PNI in different clinical subgroups.

Results

After median follow-up of 61.9 months, we found

SUBMITTER: Zhang B 

PROVIDER: S-EPMC10354907 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature