A Mendelian randomization study of serum uric acid with the risk of venous thromboembolism.

ABSTRACT:

Background

Observational studies have linked hyperuricemia with venous thromboembolism (VTE). We aimed to investigate whether there are causal relationships between uric acid levels and VTE and its subtypes, including deep venous thrombosis (DVT) of the lower extremities and pulmonary embolism (PE).

Methods

We utilized Mendelian randomization (MR) analysis to estimate the causal association in European individuals. We extracted two sets of polygenic instruments strongly associated (p < 5 × 10^-8) with uric acid from the CKDGen consortium and UK biobank, respectively. Genetic associations with the risk of VTE, DVT, and PE were obtained from the FinnGen biobank. We used the inverse-variance weighted method as the preliminary estimate. Additionally, we employed MR-Egg

SUBMITTER: Ji L 

PROVIDER: S-EPMC10354911 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature