Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion.

ABSTRACT:

Background

The mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has proved to be an efficient treatment option for cases harboring BRAF^V600 mutations (BRAF^Mut). However, there is still a significant need for effective targeted therapies for patients with other melanoma subgroups characterized by constitutive MAPK activation, such as tumors with NRAS or NF-1 alterations (NRAS^Mut, NF-1^LOF), as well as for patients with MAPK pathway inhibitor-resistant BRAF^Mut melanomas, which commonly exhibit a reactivation of this pathway. p90 ribosomal S6 kinases (RSKs) represent central effectors of MAPK signaling, regulating cell cycle progression and survival.

SUBMITTER: Kosnopfel C 

PROVIDER: S-EPMC10354913 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature