A shotgun metagenomic analysis of the fecal microbiome in humans infected with Giardia duodenalis.

ABSTRACT:

Background

The mechanisms underlying the clinical outcome disparity during human infection with Giardia duodenalis are still unclear. In recent years, evidence has pointed to the roles of host factors as well as parasite's genetic heterogeneity as major contributing factors in the development of symptomatic human giardiasis. However, it remains contested as to how only a small fraction of individuals infected with G. duodenalis develop clinical gastrointestinal manifestations, whereas the majority of infected individuals remain asymptomatic. Here, we demonstrate that diversity in the fecal microbiome correlates with the clinical outcome of human giardiasis.

Methods

The genetic heterogeneity of G. duodenalis clinical isolates from human subjects with asymptomatic and symptoma

SUBMITTER: McGregor BA 

PROVIDER: S-EPMC10354925 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature