Ontology highlight
ABSTRACT:
SUBMITTER: Martins DF
PROVIDER: S-EPMC10355051 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Martins Daniel F DF Sorrentino Victor V Mazzardo-Martins Leidiane L Reed William R WR Santos Adair R S ARS Gadotti Vinícius M VM Zamponi Gerald W GW
Molecular brain 20230718 1
The present study was undertaken to explore the relative contributions of Cav3.2 T-type channels to mediating the antihyperalgesic activity of joint manipulation (JM) therapy. We used the chronic constriction injury model (CCI) to induce peripheral neuropathy and chronic pain in male mice, followed by JM. We demonstrate that JM produces long-lasting mechanical anti-hyperalgesia that is abolished in Cav3.2 null mice. Moreover, we found that JM displays a similar analgesic profile as the fatty aci ...[more]