Biomolecule-releasing bioadhesive for glenoid labrum repair through induced host progenitor cell responses.

ABSTRACT: Glenoid labral tears occur with repetitive dislocation events and are common injuries observed in shoulder arthroscopic procedures. Although surgery can restore shoulder anatomy, repair is associated with poor clinical outcomes, which may be attributed to the poor regenerative capability of glenoid labral fibrocartilage. Thus, this study was designed to assess whether in situ tissue regeneration via biomolecule-stimulated recruitment of progenitor cells is a viable approach for the regeneration of labral tears. We developed a click chemistry-based bioadhesive to improve labral repair and reduce local inflammatory responses due to trauma. Additionally, we previously identified the presence of progenitor cells in the human labrum, which can be recruited by platelet-derived growth factor (PDG

SUBMITTER: Co CM 

PROVIDER: S-EPMC10355087 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature