Site-selective carbonylation of arenes via C(sp²)-H thianthrenation: direct access to 1,2-diarylethanones.

ABSTRACT: Herein, a new reaction for the site-selective carbonylation of arenes via C(sp²)-H thianthrenation under mild conditions has been developed. With low loadings of palladium catalysts, various desired 1,2-diarylethanones are produced in good yields. This strategy also enables the late-stage modification of complex molecules, which was previously challenging with similar carbonylative Negishi-type reactions.

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10355103 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature