Disrupting Crystal Growth through Molecular Recognition: Designer Therapies for Kidney Stone Prevention.

ABSTRACT: Aberrant crystallization within the human body can lead to several disease states or adverse outcomes, yet much remains to be understood about the critical stages leading to these events, which can include crystal nucleation and growth, crystal aggregation, and the adhesion of crystals to cells. Kidney stones, which are aggregates of single crystals with physiological origins, are particularly illustrative of pathological crystallization, with 10% of the U.S. population experiencing at least one stone occurrence in their lifetimes. The human record of kidney stones is more than 2000 years old, as noted by Hippocrates in his renowned oath and much later by Robert Hooke in his treatise Micrographia. William Hyde Wollaston, who was a physician, chemist, physicist, and crystallographer,

SUBMITTER: Shtukenberg AG 

PROVIDER: S-EPMC10355143 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature