Effect of increasing dialyzer mass transfer area coefficient and dialysate flow on clearance of protein-bound solutes: a pilot crossover trial.

ABSTRACT:

Background

Protein-bound solutes are poorly cleared by means of conventional hemodialysis because protein binding limits the "free" solute concentration driving diffusion. This study tested the modeled prediction that clearances of bound solutes could be increased by increasing the dialyzer mass transfer area coefficient (K(o)A) and dialysate flow (Q(d)) to greater than the levels used in conventional practice.

Study design

Pilot crossover trial.

Setting & participants

6 stable long-term hemodialysis patients.

Intervention

Study participants underwent an experimental dialysis treatment in which K(o)A and Q(d) were increased by using 2 dialyzers in series and supplying each dialyzer with a Q(d) of 800 mL/min by using 2 dialysis machines. Experimental clearances

SUBMITTER: Luo FJ 

PROVIDER: S-EPMC10355144 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature