Advances in SARS-CoV-2 receptor-binding domain-based COVID-19 vaccines.

ABSTRACT:

Introduction

The Coronavirus Disease 2019 (COVID-19) pandemic has caused devastating human and economic costs. Vaccination is an important step in controlling the pandemic. Severe acute respiratory coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, infects cells by binding a cellular receptor through the receptor-binding domain (RBD) within the S1 subunit of the spike (S) protein. Viral entry and membrane fusion are mediated by the S2 subunit.

Areas covered

SARS-CoV-2 S protein, particularly RBD, serves as an important target for vaccines. Here we review the structure and function of SARS-CoV-2 S protein and its RBD, summarize current COVID-19 vaccines targeting the RBD, and outline potential strategies for improving RBD-based vaccines. Overall, this review provide

SUBMITTER: Guan X 

PROVIDER: S-EPMC10355161 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature