Ontology highlight
ABSTRACT:
SUBMITTER: Petersone L
PROVIDER: S-EPMC10355162 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20230719 10
Germinal center (GC) dysregulation has been widely reported in the context of autoimmunity. Here, we show that interleukin 21 (IL-21), the archetypal follicular helper T cell (Tfh) cytokine, shapes the scale and polarization of spontaneous chronic autoimmune as well as transient immunization-induced GC. We find that IL-21 receptor deficiency results in smaller GC that are profoundly skewed toward a light zone GC B cell phenotype and that IL-21 plays a key role in selection of light zone GC B cel ...[more]