A Th1-like CD4⁺ T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer.

ABSTRACT: Perioperative immune checkpoint inhibitors have been shown to improve prognosis in early-stage lung cancer. However, no biomarkers are known to indicate the requirement for treatment. This study aimed to identify T-cell clusters responsible for antitumor immunity in patients with early-stage lung cancer. Preoperative blood samples from 50 consecutive patients with lung cancer who were diagnosed as operable and underwent complete resection were analyzed by mass cytometry. Patients were divided into two groups: no recurrence at a minimum observation period of 851 days (median observation period: 1,031.5 days) and recurrence by the last observation date. Mass cytometry and single-cell RNA sequencing analysis of lymph nodes (LN) and tumor-infiltrating T cells were also performed. CCR4^-

SUBMITTER: Yanagihara A 

PROVIDER: S-EPMC10355164 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature