Polygenic Risk and Social Support in Predicting Depression Under Stress.

ABSTRACT:

Objective

Despite substantial progress in identifying genomic variation associated with major depression, the mechanisms by which genomic and environmental factors jointly influence depression risk remain unclear. Genomically conferred sensitivity to the social environment may be one mechanism linking genomic variation and depressive symptoms. The authors assessed whether social support affects the likelihood of depression development differently across the spectrum of genomic risk in two samples that experienced substantial life stress: 1,011 first-year training physicians (interns) in the Intern Health Study (IHS) and 435 recently widowed Health and Retirement Study (HRS) participants.

Methods

Participants' depressive symptoms and social support were assessed with question

SUBMITTER: Cleary JL 

PROVIDER: S-EPMC10355168 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature