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Cdc42 Regulates the Expression of Cytoskeleton and Microtubule Network Proteins to Promote Invasion and Metastasis of Progeny Cells Derived from CoCl₂-induced Polyploid Giant Cancer Cells.

ABSTRACT: Purpose: Our previous studies have shown that CoCl₂ can induce the formation of polyploid giant cancer cells (PGCCs) and PGCCs could produce progeny cells via asymmetric division. In this study, the molecular mechanism by which PGCCs generate progeny cells with high invasion and migration abilities was explored. Methods: In this study, PGCCs induced by CoCl₂ produced progeny cells via asymmetric division, which was observed dynamically using laser scanning confocal microscopy. Cell cycle in LoVo and Hct116 before and after CoCl₂ treatment was analyzed by flow cytometry. Cell function experiments, co-immunoprecipitation, mass spectrometry analysis, ML141 treatment, western blotting, and siRNA transfection experiments were used to demonstrate th

SUBMITTER: Zheng M

PROVIDER: S-EPMC10355212 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Dataset Information

Cdc42 Regulates the Expression of Cytoskeleton and Microtubule Network Proteins to Promote Invasion and Metastasis of Progeny Cells Derived from CoCl₂-induced Polyploid Giant Cancer Cells.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Cdc42 Regulates the Expression of Cytoskeleton and Microtubule Network Proteins to Promote Invasion and Metastasis of Progeny Cells Derived from CoCl2-induced Polyploid Giant Cancer Cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Cdc42 Regulates the Expression of Cytoskeleton and Microtubule Network Proteins to Promote Invasion and Metastasis of Progeny Cells Derived from CoCl₂-induced Polyploid Giant Cancer Cells.