Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior.

ABSTRACT: Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of Igf-I in the nervous system (Igf-I ^Δ/Δ), and demonstrated that long-term potentiation was impaired in hippocampal slices. Moreover, Igf-I ^Δ/Δ mice showed spatial memory deficits in the Morris water maze, and the significant sex-dependent differences displayed by Igf-I ^Ctrl/Ctrl mice disappeared in Igf-I ^Δ/Δ mice in the open field and rota-rod tests. Brain Igf-I deletion disorganized the granule cell layer of the dentate gyrus (DG), and it modified the relative expressions of GAD and VGLUT

SUBMITTER: Herrero-Labrador R 

PROVIDER: S-EPMC10355288 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature