Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study.

ABSTRACT:

Background

Although observational studies have shown that physical activity is a protective factor for acute pancreatitis, the causal associations between PA/ sedentary behavior and acute pancreatitis (AP) and chronic pancreatitis (CP) remain unclear.

Methods

We used Mendelian randomization as a strategy to assess the causalities between exposures and outcomes by simulating randomized experiments with genetic variation. The collected genetic variants data of physical activity were from UK Biobank, the data on sedentary behavior were also from UK Biobank, and both of them could be found in the GWAS catalog, and the data on AP and CP were from FinnGen. There were three physical activity related activity patterns (moderate to vigorous physical activity [MVPA], accelerometer-bas

SUBMITTER: Ling R 

PROVIDER: S-EPMC10355380 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature