Global variations in pubertal growth spurts in adolescents living with perinatal HIV.

ABSTRACT:

Objective

To describe pubertal growth spurts among adolescents living with perinatally acquired HIV (ALWPHIV) on antiretroviral therapy (ART).

Design

Observational data collected from 1994 to 2015 in the CIPHER global cohort collaboration.

Methods

ALWPHIV who initiated ART age less than 10 years with at least four height measurements age at least 8 years were included. Super Imposition by Translation And Rotation (SITAR) models, with parameters representing timing and intensity of the growth spurt, were used to describe growth, separately by sex. Associations between region, ART regimen, age, height-for-age (HAZ), and BMI-for-age z -scores (BMIz) at ART initiation (baseline) and age 10 years, and SITAR parameters were explored.

Results

Four thousand seven hundr

SUBMITTER:  

PROVIDER: S-EPMC10355801 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature