Sex-Specific Cerebral Blood Flow Alterations in Youth Operated for Congenital Heart Disease.

ABSTRACT: Background Lower cerebral blood flow (CBF) has previously been documented preoperatively in neonates with congenital heart disease (CHD). However, it remains unclear if these CBF deficits persist over the life span of CHD survivors following heart surgery. When exploring this question, it is critical to consider the sex differences in CBF that emerge during adolescence. Therefore, this study aimed to compare global and regional CBF between postpubertal youth with CHD and healthy peers and examine if such alterations are related to sex. Methods and Results Youth aged 16 to 24 years who underwent open heart surgery for complex CHD during infancy and age- and sex-matched controls completed brain magnetic resonance imaging, including T1-weighted and pseudo-continuous arterial spin labeling acq

SUBMITTER: Easson K 

PROVIDER: S-EPMC10356035 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature